In the paper reviewed in class called, “The relation of body fat mass and distribution to markers of chronic inflammation” the authors do an excellent job explaining the relationship between CRP and fibrinogen to body fat mass and see what effects insulin resistance produced on this relationship. Since most of us have background in science we know that CRP (C-reactive protein) produced by the liver and released by adipocytes plays a critical role in chronic inflammation. Also, we know that fibrinogen which is also synthesized by the liver is a glycoprotein that is converted by thrombin into fibrin during the blood coagulation.
The study included over 1500 participants and an array different variable such as ethnicity, gender, BMI, height, etc were used to measure their relationship to body mass. The results indeed showed that there was a correlation between the two and specified how these relationships were split up according to gender. Overall the results showed that women had higher levels of CRP and fibrinogen along with increased BMI, adipose body mass; whereas men had increased in height, weight, and waist-hip ratio. In conclusion, there was a relationship between increased levels of CRP and fibrinogen and body fat mass.
Festa, A., R. D’Agostino, K. Williams, AJ Karter, EJ Mayer-Davis, RP Tracy, and SM Haffner. "The Relation of Body Fat Mass and Distribution to Markers of Chronic Inflammation." International Journal of Obesity (2001): 1407-415. Print.
The increase in BMI and adipose body mass are not only caused by high level of CRP and fibrongen, but also caused by genetics, high glucose uptake, lack of secretion from pancreas, and much more. So, I am curious on how did the authors control these factors when they were doing the study with over 1500 people.
ReplyDeleteAs Bei stated, the increase in BMI and adipose body mass are not only caused by high levels of CRP and fibrongen. CRP levels increase and decrease daily and can increase from anything. If we are stressed or just ate something fatty the levels can increase, if we exercise they can decrease. I think that this correlation that the authors portrayed and claimed to find is biased and not fully formed. I have to wonder if they controlled the 1500 people’s diet, exercise, and stress in order to find this correlation, and I suspect they did not which would compromise their findings.
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