After reading the article about resveratrol and learning about its possible roles in the prevention of numerous pathologic processes from its cardio protective, anti-cancer, anti-oxidant, and anti-inflammatory properties, I was interested in looking more into the background of resveratrol and its content in foods.
In addition to the potential benefits mentioned above, recent studies on administration of resveratrol have also found it to extended lifespan in a number of species by altering gene expression in the heart, brain, and skeletal muscle, comparable to that induced by caloric restriction.
As for the resveratrol content in foods, below is a list of some foods with resveratrol:
Relating back to the article in class, for the daily resveratrol intake of the mice in the study to be equivalent to that to that of a human, which was 1,944mg/60kg person, one would have to consume approximately between 273-1,013L of red wine (global) or 7,477-19,4400cups of raw peanuts or 1,556-8,100cups of red grapes! This of course seems like a ridiculous amount because if anything, you’ll probably get alcohol poisoning from drinking too much wine before reaping any of the potential benefits of resveratrol. But as the paper mentioned there are commercial daily supplements that range from 50-2000mg of trans-resveratrol.
However, since resveratrol has only been mainly studied in animals, presently little is known about the effects of resveratrol in humans or the effective dose of resveratrol for chronic disease prevention in humans.
So I’m still not entirely convinced, and I definitely think the translatable effectiveness of resveratrol as potential therapeutic approach in humans is still questionable, how about you?
http://lpi.oregonstate.edu/infocenter/phytochemicals/resveratrol/#sources
http://www.createbalance.net/support/science/resveratrol_cancer_prevention.pdf
I agree, that consuming it to medically sufficient amounts seems a little out of reach. This reminds me of curcumin that we studied a while back. In order to receive some kind of medical benefits from consumption, it would have to be eaten several pounds, every day, for life. Furthermore, this delves into the realm of naturopathic medicine where they tout the benefits of eating certain foods, and while some of the benefits received from eating active ingredients in the food are there, nobody is going to eat 8,000 cups of grapes a day.
ReplyDeleteIt most definitely seems that the positive physiological effects that can be achieved through consuming red wine, because of its concentration of resveratrol, are far fetched and unobtainable, before you end up killing yourself by overdosing. However this isn't to say that there are no benefits at all. Therapeutically red wine may have an affect on relaxation and calming oneself down, that when in addition with the minuscule amounts of resveratrol, might serve a physiological purpose.
ReplyDeleteThe issue with anti-oxidant therapeutics including resveratrol is its poor bioavailability or ability of the drug to be absorbed into the blood stream from extravascular administration (e.g. oral). Several drug delivery scientists are working to improve the drug delivery of these anti-oxidants such that a reasonable dose of drug can be administered with therapeutic effects. This may be the only hope for saving the potentially therapeutic anti-oxidants.
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