14 October 2010
Two Seperate Risks Might Operate Similarly
In the article "Smoking and Sugar Intake are Separate but Interactive Risk Factors in Crohn's Disease," observations were made on individuals who subjected themselves to known risks of Crohn's disease. The paper questions whether smoking and additional processed sugar intake affect each other as risks for Crohn's disease. For many diseases such as the metabolic syndrome which was brought up earlier this year, risk factors can build additively or exponentially to greatly increase chances of developing a chronic disease. This study showed that these two risk factors do not additively increase risk for IBD. The suggestion is that these two risks might operate at the same root cause and activate the same pathway for disease development. This is a significant finding because if the mechanism can be traced using smoking of sugar intake, then perhaps a root cause for the disease can be treated and not just one possible risk factor. By searching for a multifunctional pathway, this disease would be easier to treat because eliminating every possible risk which would be unfavorable for the patient, perhaps an easier method which could simultaneously fix many areas can be discovered. Presently, one of the major areas of concern involving treating IBD is localizing it to affected areas only.
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I thought it was very interesting that smoking and sugar intake may trigger a common or similar mechanism but the combination of both did not display an additive effect on the symptoms/risk of IBD. After reading this article, I felt like the authors put a lot of trust in the patients' answers on their surveys and questionnaires. I guess I'm a little skeptical of relying soley on their answers rather than having some sort of scientific evidence to back up their claims. However, I do beleive that because a large portion of these patients are suffering from Crohn's Disease they would be more likely to take the surveys more seriously with the hopes of getting helpful results.
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