Hey guys!
I remember in class there was a question regarding CD 28- and its function. I found myself digging through my brain and eventully came to the conclusion that I didn't know what it did either! Like all science nerds, I went off on a search and finally figured it out.
In the article it was paired with CD 4. We know CD 4 is expressed on dendritic cells, macrophages T helper cells etc. It is a co-receptor that assists the T cell with the antigen-presenting cell and allows the signal to be amplified, so on and so forth.
It turns out that CD 28 is also expressed on T cells! It has an intense co-stimulatory signal for producing interleukins. CD28 also happens to be the only B7 receptor expressed on naive T cells!
There is a plethora of additional information in the journal article attached :)
http://jem.rupress.org/content/190/4/487.full
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