siRNA

small RNAs can regulate gene expression by mRNA degradation, inhibition of translation, or transcription

• Dicer protein attracted to double-stranded (abnormal) RNA and cuts it into small pieces
• RISC protein recognizes dsRNA and degrades one strand
• Other strand can direct RISC protein to the complementary mRNA it came from, so RISC can destroy it
• The “intrinsic/endogenous” process and the experimental process-similar to what the Emory/GT lab did : introduce siRNA through more innovative ways (viral vector-RISC will go looking for viral mRNA strand)